Asperger Syndrome: A Proton Magnetic Resonance Spectroscopy Study of Brain

Declan G.M. Murphy et al., Archives of General Psychiatry, Volume 59, October 2002.

Asperger Syndrome (AS; an autistic disorder) is associated with impaired social skills and obsessional/repetitive behaviour. Patients with autism have significant abnormalities in the frontal lobe and frontoparietal connectivity. Nobody has examined the relationship between abnormalities in the frontal and parietal lobes and clinical symptoms in people with AS. Subjects with AS have abnormalities in neuronal integrity of the prefrontal lobe, which is related to severity of clinical symptoms.